Macrophage Phagocytosis
Phagocytosis involves a series of events, starting with the recognition and binding of cell surface receptors to the particles, then forming an actin-rich membrane extension around the particle, and finally, the membrane extensions fuses to form phagosomes. Pathogens in the phagosomes are destroyed by lowered pH, hydrolysis, and radical attack. These early events, mediated by the innate immune system, are critical to the survival of the host. As a result of this process, pathogen-derived molecules can be presented at the cell surface (antigen presentation), allowing the induction of acquired immunity.
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