adcp assay
Monoclonal antibodies (mAbs) are successful as therapeutics due in part to their ability to induce the destructive capabilities of the immune system against specific target cells. mAbs activate antibody-dependent cellular cytotoxicity (ADCC) by natural killer (NK) cells and antibody-dependent cellular phagocytosis (ADCP) by macrophages, and these activities are considered to be important mechanisms of action for many of these mAbs in vivo. Several mAbs also activate the classical complement pathway and promote complement-dependent cytotoxicity (CDC), although the level of efficacy varies greatly, depending on the mAb, the target antigen, and the tumor type. All of these effector functions are mediated by the Fc region of antibody and over the past decade, engineering of this region to enhance the cytotoxic activity of therapeutic antibodies has been a subject of intense investigation.
adcp
Side Score: 0
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assay
Side Score: 0
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