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Winning Position: Unresolved
Creative Biolabs offers a full range of vaccine-based anti-monkeypox drug discovery solutions to explore novel effective vaccines against monkeypox that have lower toxicity and fewer side effects. We combine traditional and cutting-edge technologies, including high-throughput screening, artificial intelligence, in vitro and in vivo platforms, and monkeypox detection services, to assist our global clients in discovering effective vaccines against the monkeypox virus. We provide DNA and mRNA vaccine-based anti-monkeypox solutions, monkeypox-like particle-based vaccine solutions, as well as monkeypox vaccine discovery solutions.
Winning Position: Unresolved
Complement regulators control the spontaneously activated complement cascade. At the same time, any disturbances in this delicate balance can cause damage to tissues and autoimmune disease. Table 1 is listed seven complement regulators. In the table, MCP refers to the memebrane cofactor protein and DAF means the decay accelerating factor. C1 INH means C1 inhibitor. GPI is glycosylphosphatidylinositol.
Winning Position: Unresolved
Introduction of Tetanus Toxoid
Tetanus is a vaccine-preventable disease that is caused by a potent neurotoxin produced by the spore-forming bacterium Clostridium tetani. The spores of C. tetani are present in the environment throughout the world and can contaminate wounds, minor abrasions, and, in neonatal tetanus, the umbilical stump. In anaerobic conditions, the spores of C. tetani produce vegetative bacteria, which express the tetanus toxin and cause the disease.
Winning Position: Unresolved
The phylogenetically closest virus to variola, the cause of smallpox, is the taterapox virus (TATV). Despite the resemblance, the virus has not been thoroughly studied. TATV can infect a variety of animals in vivo, but it has no noticeable effect on mice of the wild type. However, in some immunocompromised strains, TATV can cause morbidity and mortality.
Winning Position: Unresolved
The presence of CLU has been associated with a protective function from complement-mediated injury or from potentially damaging agents of the extracellular environment. The association between CLU and complement proteins has been reported in different human pathological conditions suggesting a protective effect of CLU under stress conditions.
Winning Position: Unresolved
Design and Synthesis of Haptens for TartrazineCreative Biolabs is focused on providing rapid and effective solutions in hapten design and synthesis for small molecules. We pride ourselves on our professional team of antibody discovery and hapten studies. In our services, you can rely on professional project management and advanced technologies to help the success of your projects. We can provide you with a comprehensive solution package to guide your projects from the tartrazine hapten design to antibody commercialization.
Winning Position: Unresolved
Creative Biolabs is very proud to provide comprehensive mRNA vaccine-based anti-monkeypox drug discovery solutions to discover effective mRNA vaccines against monkeypox with low toxicity, few side effects, and high stability. We provide anti-monkeypox products and services, including but not limited to high-throughput screening, artificial intelligence, in vitro and in vivo platforms, and monkeypox detection services. Our dedicated team helps you design customized monkeypox mRNA vaccines for your specific application and assists you in solving your expertise questions.
Winning Position: Unresolved
Complement receptors (CRs), a number of G protein-coupled receptors (GPCRs), are usually expressed on different immune cells and are responsible for mediating the inflammatory responses in humans. Four types of CRs have been identified, including CR1, CR2, CR3, and CR4, in the past few years of studies.
Winning Position: Unresolved
Melamine is a high nitrogen compound that may be illegally added to inflate the apparent protein content of food products. The adulteration with melamine has led to an urgent requirement for sensitive, specific, rapid, and reliable quantitative/screening methods. Based on rational hapten modification and antibody development for melamine, the immunoassay detection of melamine in milk, milk powder, and feed samples has been increasingly prosperous. To promote the development of screening methods for melamine analysis, Creative Biolabs provides comprehensive hapten services, including but not limited to melamine hapten design, modification, and synthesis, as well as subsequent antibody discovery, labeling, and characterization.
Winning Position: Unresolved
The design, modification, and synthesis of metal-chelate hapten are the first steps to produce antibodies with bound heavy metals hapten that have many potential uses in medicine. As a leading provider in the field of hapten design, Creative Biolabs can accomplish customers' challenging projects for the best-fit design and synthesis of heavy metals hapten.
Winning Position: Unresolved
At present, iPSC for 3D bio-printing technology is mainly used in drug testing, through the cultivation of organ-on-a-chip to test the effectiveness and toxicity of drugs. Due to the complex functions of human organs, many drugs showed significant efficacy in animals but failed in clinical trials since organs in the human body may accidentally digest, swallow, or even degrade the medicine. A very meaningful technology is called "human-on-a-chip" to integrate human tissue into a microfluidic device to simulate human blood runoff from various organs. This technology not only avoids animal experiments and human experiments that are ethically controversial, and saves the cost of clinical trials, but it can also better eliminate drug toxicity and find more effective drugs or treatment strategies to truly benefit patients.
Winning Position: Unresolved
γδ T cells contribute to host protection against infections and represent an integral part of the functional immune system in higher vertebrates. With access to advanced instruments, fit-for-purpose laboratories, and professional knowledge, Creative Biolabs provides a full range of services to support our clients in γδ T cells development, especially γδ T cell hybridomas development.
Winning Position: Unresolved
Immunoassays are regarded as an effective and economical screening method by virtue of their high throughput, strong sensitivity, and fast analysis. In the last decades, several immunodetections have been developed to detect AVMs based on monoclonal or polyclonal antibodies. At Creative Biolabs, we have rich knowledge and experience in antibody production and are dedicated to providing speedy, simple, and sensitive methods for clients to prepare high-quality AVM haptens.
Winning Position: Unresolved
Creative Biolabs is dedicated to providing several viable and cost-effective methods for iPSC differentiation. With our well established iPSC technology platform, we have the capability to generate iPSC from patient material, either normal or diseased. A variety of cell types can be generated from these iPSCs, such as neuronal cells, hepatocytes, and cardiomyocytes.
Winning Position: Unresolved
The human γδ T cell is a small group of T lymphocytes carrying a distinctive γδ cell receptor, which has an enhanced antigen-presenting function after activation. With abundant experience in cell bioengineering during the past decades, Creative Biolabs has developed an advanced technology platform to provide rapid and high-quality γδ T-APC development services for clients throughout the world.
Winning Position: Unresolved
Combine years of experience in the development of anti-hapten antibodies and our capacity in hapten design, Creative Biolabs offers custom services for the development of anti-hapten monoclonal and polyclonal antibodies, which are particularly suited to diagnostic and theranostic applications.
Winning Position: Unresolved
Nevertheless, in order to ensure the maximum gene targeting efficiency and specificity, a great variety of design considerations should be taken into account. It is especially important when engineering induced pluripotent stem cells (iPSCs), because they are more difficult to transfect and less resilient to DNA damage than immortalized tumor cell lines. With years of exploration in iPSC development, Creative Biolabs is dedicated to providing a full range of iPSC genome editing services for customers all over the world.
Winning Position: Unresolved
Antibodies are a group of glycoproteins naturally produced by the immune system with activities of defense against a variety of external and internal antigens, which has been widely applied in the clinic including the prevention, diagnosis, and treatment of diseases. The advent of the hybridoma technology by Köhler and Milstein in 1975 made it possible to produce identical monoclonal antibodies on a large scale. Creative Biolabs is a leading service provider that focuses on antibody engineering for research, diagnostic and therapeutic use. With extensive experience in antibody development, our scientists are able to provide superior engineering services about anti-glycan antibodies.
Winning Position: Unresolved
And although animal models have greatly informed current views on these disorders, they have often failed to recapitulate key aspects of the diseases. Thus, reductionist in vitro approaches using human cells, such as the analysis of patient-derived neurons generated using induced pluripotent stem cells (iPSC), have been met with particular excitement.
Winning Position: Unresolved
hapten purificationArtificial antigen obtained by coupling hapten derivative with the carrier must be purified to remove un-reacted hapten, salts, and other small molecules. Creative Biolabs can use dialysis and gel chromatography methods to purify the artificial antigen to remove un-reacted hapten, salts, and other small molecules. The identification of purified hapten should contain qualitatively identified whether the hapten derivative has been coupled with carrier protein successfully, and quantitatively determined the ratio of protein to the hapten.
Winning Position: Unresolved
iPSC for Drug Development
There are many potential reasons for drug discovery from the molecular and animal model level to the failure of human therapeutics. In particular, the success of the preclinical phase of drug development is based on animal models. Drug discovery/development platforms using iPSC-based disease models may help fill the gap between animal models and clinical trials.
Winning Position: Unresolved
Antibody detection and identification are significantly important to the differential diagnosis of many different pathological conditions. Dedicated to antibody research and development for decades of years, Creative Biolabs provides remarkable antibody related services. Our professional academic teams are confident in applying our experience, industry and regulatory knowledge to offer a tailored, professional and satisfying solution to customers' projects.
Winning Position: Unresolved
The complement system, also known as complement cascade, is an important part of the innate immune response consisting of a series of small proteins in the plasma or on cell surfaces. All the complement proteins interact and work together to “complement” or enhance the immune system to fight against pathogens. Currently, the complement system is recognized as a key bridge between the innate and adaptive immune systems to keep the immune homeostasis of organisms.
Winning Position: Unresolved
Since its original isolation, evidence has been growing to support the significance of strains belonging to Anaerostipes hadrus (A. hadrus) within the human GI tract. Creative Biolabs is a CRO company focused on live biotherapeutic products (LBP) development, we offer our technical expertise and experience to provide traceable, customizable solutions.