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Winning Position: Unresolved
Preclinical drug studies play an important role in the drug development process. Only drugs that have completed preclinical drug studies can successfully enter clinical trials. Ace Neuroscience has decades of experience in providing quality services for the comprehensive evaluation of stroke drug candidates. Our scientists strictly control every aspect of the study to ensure its authenticity, reproducibility, and scientific validity. Our professional and responsible approach is designed only to facilitate the successful development of your stroke drug.Learn more: Drug Therapy in Stroke
Winning Position: Unresolved
It is an important research tool to explore the role played by differential targets in stroke pathology and the cascade of responses it involves. Studies on stroke pathogenesis can be more specific and the results can be more detailed by starting with differential targets. Therefore, Ace Neuroscience provides a quality service to comprehensively explore the role of differential targets in the pathological process of stroke. Our services target targets in the areas of nucleic acids and proteins. For different types of targets, we provide the most specialized and comprehensive services to accelerate your stroke research.Learn more:therapeutic targets for stroke
Winning Position: Unresolved
Glaucoma is a group of ocular diseases that may lead to progressive retinal ganglion cell death and irreversible vision loss. Although our understanding of glaucoma is much more advanced than before, our understanding of its molecular mechanisms still requires a great deal of basic research to further understand it.Ace Ophthalmology' research team consists of leading scientists studying the mechanisms of glaucoma and glaucoma treatment, and we collaborate in basic research, therapy development, and preclinical studies in glaucoma. The main areas of basic glaucoma research include genetics, genomics, proteomics, metabolomics, and biomechanics of glaucoma. We are committed to conducting extensive research to better manage glaucoma and to provide possible directions for glaucoma treatment.Learn more:glaucoma basic research services
Winning Position: Unresolved
With the improvement of living standards, the prevalence of diabetes is on the rise all over the world. It has become another non communicable chronic disease that seriously endangers human health.What is DiabetesThe main types of diabetes include type 1 diabetes mellitus (T1DM), type 2 diabetes mellitus (T2DM), gestational diabetes (diabetes while pregnant) and other special types of diabetes. The T2DM is the main disease, accounting for about 95%.Type 1 Diabetes MellitusT1DM is a genetic and immune disruption autoimmune disease that results in massive β-cell destruction. It is recognized to result from a complex interplay between environmental factors and microbiome, genome, metabolism, and immune systems that vary between individual cases.Type 2 Diabetes MellitusT2DM is characterised by relative insulin deficiency caused by pancreatic β-cells dysfunction and insulin resistance in target organs. It develops over many years and is usually diagnosed in adults.Gestational DiabetesGestational diabetes (GDM) is the third main form, and occurs when pregnant women without a previous history of diabetes develop high blood sugar levels. Risk factors include being overweight, previously having gestational diabetes, a family history of type 2 diabetes, and having polycystic ovarian syndrome. In women with gestational diabetes, blood sugar usually returns to normal soon after delivery.The Immunopathogenesis of T1DM (Linda, A. D.; et al. the lancet, 2018)
Winning Position: Unresolved
To be more detailed, in the H. pylori vaccine antigen optimization services, we provide H. pylori vaccine antigen expression optimization and antigen combination optimization services. And in the H. pylori vaccine antigen preparation and custom synthesis services, we offer antigen preparation and custom synthesis for H. pylori whole-cell vaccines, H. pylori subunit vaccines, and H. pylori DNA vaccines.In the long-term development of H. pylori vaccine antigens, we have accumulated numerous development experiences and formed our unique competitive advantages.
Winning Position: Unresolved
H. pylori genetic polymorphismsH. pylori infection can cause a variety of gastrointestinal disorders, including gastritis, gastric ulcers, gastric cancer, and duodenal ulcers. The formation of different diseases caused by H. pylori is associated with GPs in both H. pylori and humans, as well as environmental factors. For example, H. pylori strains with cagA gene have a greater ability to cause disease, and the EPIYA (Glu-Pro-Ile-Tyr-Ala) and multimerization (CM) motifs have been reported to contribute to disease progression. The gene types associated with gastric cancer risk in VacA are the s1, m1, and i1 genotypes. In humans, IL-1β-31T+ and IL-1RN*2/*2 of the IL-1 loci increased the risk of gastric cancer. And individuals carrying the TNF-α-308 have an increased risk of gastric cancer.
Winning Position: Unresolved
Antimicrobial Peptides DevelopmentSome promising natural product candidates are antimicrobial peptides (AMPs) from various organisms, which represent some of the possible solutions against superbugs. Our service is to help researchers find natural AMPs, explore their mechanisms of antimicrobial activity, and optimize antimicrobial activity and minimize toxicity and production costs, using AMP as a natural model for developing novel antibiotics in the future.Antibiotic Adjuvants DevelopmentSmall molecule antibiotic adjuvants work by hindering the bacterial resistance mechanism and making the bacteria sensitive to antibiotics. We offer several services for developing potential antibiotic adjuvants, including adjuvants that inhibit the degradation of antibiotics by β-lactamases, modulate the permeability of bacterial extracellular membranes, or increase the intracellular concentration of antibiotics by inhibiting efflux.Monoclonal Antibodies Development Against SuperbugsMonoclonal antibodies can treat bacterial infections by a variety of mechanisms and are often safe and well-tolerated. Antibodies complement antibiotic therapy and have efficacy against resistant strains of bacteria. We offer services for the development of exciting next generation antibodies against superbugs, which include antibodies with different mechanisms of action and different forms of antibodies designed.Phage Therapies Development Against SuperbugsIn the context of today's progressive rise in antibiotic resistance, phages are increasingly being used to treat chronic bacterial infections that have become resistant to multiple antibiotics. We provide development services including phage discovery, isolation, characterization, cocktail design, engineering, and preclinical development programs for phage drug discovery.Developing drugs against superbugsThe development of vaccines against superbugs is an important area of research because vaccines can help prevent infections from occurring in the first place and reduce the need for antibiotics. We provide development services of vaccine against superbugs with fast turnaround times, cost-effectiveness, and unparalleled technical expertise.
Winning Position: Unresolved
Stroke medicationStroke affects many people worldwide. However, due to the complexity of stroke and the very short treatment window, there are no effective therapies for stroke. Ace Neuroscience has more than a decade of research experience in the stroke field. Based on our extensive research experience and advanced technology platform, we are committed to facilitating progress in stroke drug development and helping you with your stroke drug development research.
Winning Position: Unresolved
In the long-term development of H. pylori Vaccine Antigens Development, we have accumulated numerous development experiences and formed our unique competitive advantages.Comprehensive development serviceAce Infectious provides systematic H. pylori vaccine antigen development services, including discovery, selection, optimization, preparation, and custom synthesis of H. pylori vaccine antigens. In addition, we have relevant basic services, such as quality testing services, immunogenicity testing services, and safety testing services.Professional awarenessOwing to the complex host response to the pathogen, the successful development of H. pylori vaccines requires an understanding of the immune mechanisms during natural infection by H. pylori and the factors that allow the persistence of H. pylori. This means that the immunogenicity and biochemical properties of H. pylori vaccine antigens are of great importance for vaccine development. And Ace Infectious focuses on these aspects of H. pylori vaccine antigens.