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Winning Position: Unresolved
Methylation-Based Biological Age and Cancer RiskChanges in DNA methylation levels with age, and it has been widely studied as a well-known biomarker of aging. A number of DNA methylation age clocks have appeared and been used, and when the age predicted by the methylation clock is greater than the actual age, it is considered to have "age acceleration", which is also called the biological measure of aging.Research suggests a correlation between aging and cancer as well. Predicted ages obtained by DNA methylation analysis are greater than actual ages, indicating age acceleration, and these phenomena may also be strongly associated with cancer risk. By analyzing the age acceleration of DNA methylation to discover their association with increased cancer risk or shorter survival, it could help to understand specific relationship between the aging process and cancer development, developing DNA methylation as a tool for predicting cancer risk.
Winning Position: Unresolved
The aging of today's global population is accelerating, leading to a higher incidence of some diseases related to aging, such as chronic diseases, neurodegenerative diseases, cardiovascular diseases, etc. However, people at the same age may show different disease expressions, and one possible factor is due to differences in the aging process of different individuals, which means that the actual age of individuals is the same but their biological age may be different.Then understanding the biological age and aging rate of different individuals, the latter is also known as age acceleration, can help us identify high incidence groups and is important for early disease prevention.
Winning Position: Unresolved
Black carrot, a member of the parsley family, is known as a fruit. It is rich in anthocyanin. Anthocyanin is the pigment that gives black carrots its distinctive black color. The color of anthocyanin-like substances varies depends on pH. If the pH is less than 7, it will appear red. Anthocyanin is mainly used in food coloring, but also in dyes, pharmaceuticals and cosmetics. black carrot red pigment has a red water-soluble anthocyanin color. It is used for coloring organic products due to its natural coloring effect.
Winning Position: Unresolved
Introduction to Target-Based Peptidomimetic DevelopmentAn in-depth understanding of the function and pathology of cells provides many potential targets for the development of new therapeutic and diagnostic agents. However, a general problem with translating this knowledge into therapeutics is that these targets are functionally incapable of drug development. Screening methods similar to mRNA display and phage display have been shown to generate peptidomimetics capable of binding to and modulating PPI for the study of a wide range of protein interactions. Undoubtedly, the identification and better understanding of the interaction between peptidomimetics and their therapeutic targets has dramatically changed the paradigm of drug discovery.
Winning Position: Unresolved
Overview of Chemical Conjugation-based VLP Modification ServiceTo overcome the disadvantages of being limited by antigen size, conformation and assembly of VLPs when constructing cVLPs using genetic fusion methods. We offer chemical conjugation methods to construct cVLP from VLPs generated from plant platforms. In this strategy, the target antigen and VLPs are first produced separately and subsequently linked together by attaching the antigen to the surface of the VLPs. Antigens can be covalently or non-covalently bonded to VLPs constructed from plant platforms to form cVLPs. The most common covalent method is through the use of heterobifunctional chemical crosslinkers with amine and sulfhydryl reactive arms. For example, cysteine-containing antigens can be embedded to VLPs with amino acid residues on their surface. Non-covalent coupling strategies include the use of streptavidin as a junction to link biotinylated antigens and VLPs through their specificity and strong interactions.Advantages of Chemical ConjugationThis approach allows for the attachment of antigens of different sizes and types to VLPs, including non-protein antigens, and also allows for the manipulation of the binding sites of antigens to VLPs to maximize exposure of conjugated antigens. This ability is essential for the development of vaccines against pathogens with antigenic versatility, as larger proteins are more effective than shorter peptides at eliciting antibodies and eliciting an immune response.Common conjugation chemistries. (Rohovie MJ, et al., 2017)
Winning Position: Unresolved
Cytoskeleton-related Research ServiceAlzheimer's disease continues to destroy brain tissue, causing patients to lose memory and experience disorientation, among other things, potentially rendering them unable to care for themselves in their daily lives.Mechanisms of Alzheimer's DiseaseAlzheimer's disease (AD) is the leading cause of dementia and is a progressive neurodegenerative disease. Dementia includes memory loss and difficulties with thinking, language, and problem-solving skills.Aβ Plaque Associated Neurodegeneration: Aβ plaques form and are deposited in different areas of the brain. These plaques are recognized by the brain as foreign bodies and trigger inflammatory and immune responses by activating microglia and releasing cytokines, ultimately leading to cell death and neurodegeneration.Neurofibrillary Degeneration: Over-activation of cyclin-dependent kinase 5 (CDK5) and leads to tau hyperphosphorylation. Hyperphosphorylation leads to a decrease in the affinity of tau proteins for microtubules. The hyperphosphorylated tau forms NFTs and is deposited in the cytoplasm where it no longer functions to maintain cellular structure.Neuroinflammation: Neuro-inflammation plays a central role in the pathogenesis of AD. Acute inflammation has a protective role in defending against brain injury such as the presence of Aβ plaque.The Abnormal tau Modification Theory of Alzheimer's DiseaseTAU protein is a microtubule-associated protein. Under normal conditions phosphorylated tau protein binds to microtubules, helps maintain their dynamic stability, and plays an important role in neuronal material transport and information transmission.The abnormal modification of tau protein in Alzheimer's disease is believed to be the result of hyperphosphorylation, which weakens the ability of tau protein to bind to microtubule proteins, destroying the cytoskeleton and producing abnormal neurofibrillary tangles (NFTs) that can be observed under light microscopy, while the microtubules are unable to transport relevant substances due to deformation, and the axons and dendrites of distal neurons atrophy due to lack of nutrients, thus triggering Alzheimer's disease. Alzheimer's disease.
Winning Position: Unresolved
Changes in DNA methylation levels with age, and it has been widely studied as a well-known biomarker of aging. A number of DNA methylation age clocks have appeared and been used, and when the age predicted by the methylation clock is greater than the actual age, it is considered to have "age acceleration", which is also called the biological measure of aging.Research suggests a correlation between aging and cancer as well. Predicted ages obtained by DNA methylation analysis are greater than actual ages, indicating age acceleration, and these phenomena may also be strongly associated with cancer risk. By analyzing the age acceleration of DNA methylation to discover their association with increased cancer risk or shorter survival, it could help to understand specific relationship between the aging process and cancer development, developing DNA methylation as a tool for predicting cancer risk.Application AreasGastric cancer researchLung cancer researchKidney cancer researchBreast cancer researchLymphoma researchRectal cancer research
Winning Position: Unresolved
Introduction of measurement services of root physiological characteristicsRoot morphological traits are important for maximizing water and mineral uptake. As plants growing in the natural environment are subject to a variety of factors, plant roots often modify their nutrient acquisition capacity by adapting their morphological and/or physiological characteristics to meet changes in shoot nutrient requirements in response to environmental stresses. Drought is one of the most common factors that threaten healthy plant growth and development. Understanding the physiological traits of roots associated with drought tolerance is important for further understanding the drought tolerance mechanisms of the whole plant.
Winning Position: Unresolved
Biofilm Analysis ApproachesWe are committed to providing comprehensive services for biofilm analysis. We use advanced analytical techniques and our biofilm analysis services include but are not limited to:Quantitative Characterization of BiofilmsQualitative Characterization of BiofilmsBiofilm Total Protein Determination Quantitative Analysis of Bacteria in Biofilms Biofilm Imaging Services Biofilm Genomics and Metagenomics Services Biofilm Transcriptomics Services Biofilm Proteomics Services Biofilm Metabolomics Services Biofilm TOC Analysis Services Interaction Analysis of Biofilm Community Biofilm Interface Analysis Feature Analysis of Biofilm Formation Biofilm Microelectrode Analysis Biofilm Interaction Analysis Biofilm Volume and Morphology Analysis Biofilm ATP Bioluminescence Analysis
Winning Position: Unresolved
The aging of today's global population is accelerating, leading to a higher incidence of some diseases related to aging, such as chronic diseases, neurodegenerative diseases, cardiovascular diseases, etc. However, people at the same age may show different disease expressions, and one possible factor is due to differences in the aging process of different individuals, which means that the actual age of individuals is the same but their biological age may be different.Then understanding the biological age and aging rate of different individuals, the latter is also known as age acceleration, can help us identify high incidence groups and is important for early disease prevention. As a biological service provider for aging research, we can provide services for association studies between age acceleration and disease expression on the basis of DNA methylation analysis.
Winning Position: Unresolved
The plant cell wall is a complex matrix containing heterogeneous glycans, which controls the morphology, growth and development of plants. It is the plant's first barrier against a variety of biotic/abiotic stresses. Despite the important role that the cell wall plays in plant development, understanding the structural characteristics and functions of its components remains challenging due to the limitations of available technologies.The complexity of the structural units of cell wall glycans, the glycosyl residues, results in their conformational and chemical diversity. Some studies have shown a link between alterations in wall glycans and disease resistance in crops. Given the important role of wall glycans in plant immunity, it is necessary to establish new methods to characterize the different ranges of glycan structures. Monoclonal antibodies (mAb) developed against cell wall polymers are now an important tool for determining the structure and distribution of glycans in plant cell walls.Learn more:glycan profiling services of plant cell wall polymers
Winning Position: Unresolved
Identifying and characterizing the phenotype of Drosophila models is a breakthrough in the study of molecular mechanisms. Thereby, we provide our clients with comprehensive in vivo Drosophila phenotypes services, both at the physiological level and at the metabolic molecular level. We use our extensive knowledge to help clients overcome technical challenges and bottlenecks in quantifying disease mutations and phenotypes for drug action. We look forward to a win-win collaboration with our clients.Learn more:Drosophila Phenotype
Winning Position: Unresolved
We employ advanced techniques to gain comprehensive insights into the molecular mechanisms underlying aging processes. We are committed to accelerating progress in the field of aging-related diseases, striving to advance the discovery of treatments and therapeutics for a wide spectrum of conditions such as Alzheimer's disease, osteoporosis, arthritis, Parkinson's disease, cardiovascular diseases, and aging-related macular degeneration.Learn more:aging research